ODCs

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1 OMIM reference -
1 associated gene
13 signs/symptoms

PROTEIN INTERACTIONS: 1

Mantle cell lymphoma

3 associated genes
7 signs/symptoms

IMAGe syndrome

Mantle cell lymphoma

CDKN1C	(UniProt - OMIM)		ATM	(UniProt - OMIM)
			CCND1	(UniProt - OMIM)
			IGH	(UniProt)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	CDKN1C	(0.75)	CCND1

Citations in the biomedical literature:

IMAGe syndrome		Mantle cell lymphoma
	Synonym(s): - Intrauterine growth retardation - metaphyseal dysplasia - adrenal hypoplasia congenita - genital anomalies		Synonym(s): - LCM - MCL - Mantle zone lymphoma

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare urogenital disease		Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: no data available Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: adult Type of inheritance: multigenic/multifactorial

	External references: 1 OMIM reference - No MeSH references		External references: No OMIM references 1 MeSH reference: D020522

IMAGe syndrome		Mantle cell lymphoma
	Very frequent - Adrenal glands anomalies - Anomalies of bones / skeletal anomalies - Autosomal recessive inheritance - Depressed nasal bridge - Frontal bossing / prominent forehead - Hypospadias / epispadias / bent penis - Hypotonia - Intrauterine growth retardation - Late puberty / hypogonadism / hypogenitalism - Low set ears / posteriorly rotated ears - Megaureter / hydronephrosis / pyeloureteral junction syndrome - Short limbs / micromelia / brachymelia - Undescended / ectopic testes / cryptorchidia / unfixed testes		Very frequent - Hematologic / blood / lymphatic cancer - Lymphadenopathy / polyadenopathies Frequent - Anorexia - Asthenia / fatigue / weakness - Bone marrow / medullar infiltration - Splenomegaly - Weight loss / loss of appetite / break in weight curve / general health alteration